---
product_id: 274232883
title: "II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply"
brand: "advantage"
price: "89986CFA"
currency: XOF
in_stock: true
reviews_count: 5
category: "Advantage"
url: https://www.desertcart.sn/products/274232883-ii-large-dog-vet-recommended-flea-treatment-and-prevention-dogs
store_origin: SN
region: Senegal
---

# Waterproof after 24 hours Kills fleas within 12 hours 4-month continuous protection II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply

**Brand:** advantage
**Price:** 89986CFA
**Availability:** ✅ In Stock

## Summary

> 🦴 Stay ahead of fleas—because your dog deserves the best defense!

## Quick Answers

- **What is this?** II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply by advantage
- **How much does it cost?** 89986CFA with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.sn](https://www.desertcart.sn/products/274232883-ii-large-dog-vet-recommended-flea-treatment-and-prevention-dogs)

## Best For

- advantage enthusiasts

## Why This Product

- Trusted advantage brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Defense:** One application delivers a full 30-day shield against fleas and lice.
- • **Effortless Application:** Topical, fragrance-free formula goes on in seconds—ditch the pills and collars.
- • **Rapid Flea Elimination:** Starts killing fleas on contact within 12 hours—no biting needed.
- • **Subscription Convenience:** Never miss a dose with doorstep deliveries—keep your dog flea-free year-round.
- • **Vet-Recommended Reliability:** Trusted by professionals to protect dogs 21-55 lbs from flea-borne health risks.

## Overview

Advantage II Large Dog is a vet-recommended topical flea and lice treatment for dogs weighing 21-55 lbs. It kills adult fleas, larvae, and eggs within 12 hours through contact, breaking the flea life cycle with monthly applications. Waterproof after 24 hours and fragrance-free, it offers a convenient, prescription-free solution to protect dogs from flea-related health issues for up to 4 months.

## Description

Advantage II Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Large Dog topical treatment gets straight to work killing fleas through contact, so they don&x2019;t have to bite your dog to die. This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia. That&x2019;s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You&x2019;ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21 to 55 lbs. to use Advantage II Large Dog. For the ultimate convenience in care, Advantage II Large Dog is available over the counter &x2013; no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Large Dog is applied, your dog is ready to get right back to exploring his favorite places &x2013; from the backyard to the dog park. Advantage II Large Dog is a trademark of Elanco or its affiliates.

Review: Works for all 3 of my dogs, no fleas, no ticks! I buy this product every summer!
Review: I have never had a problem getting rid of fleas with Advantage

## Features

- Item Category: Pet Pest Control
- Item Trademark: Bayer
- manufacturer: Bayer

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B004QRFJA4 |
| Batteries Included | No |
| Customer Reviews | 4.4 4.4 out of 5 stars (2,179) |
| Date First Available | 7 August 2012 |
| Item Form | Topical |
| Item Weight | 45.4 g |
| Item model number | 86336707 |
| Number of Items | 4 |
| Pet Life Stage | 7 weeks and older |
| Product Dimensions | 16.51 x 2.54 x 10.8 cm; 45.36 g |
| Quantity | 1 |
| Size | 4-Pack |
| Volume | 10 Milliliters |
| batteries required | No |

## Product Details

- **Active Ingredients:** Imidacloprid, Pyriproxyfen
- **Brand:** Advantage
- **Item form:** Topical
- **Item weight:** 0.1 Pounds
- **Scent:** Unscented

## Images

![II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply - Image 1](https://m.media-amazon.com/images/I/71cacwZn0PL.jpg)

## Questions & Answers

**Q: Is there a warning to keep the dog away from cats for 24 hours after treatment with Advantage, as is found on Frontline?**
A: Yes, there is a seperate and specific warning about not using it on cats and keeping dogs away from cats for 24 hrs. Highlited in yellow.

**Q: Is it ok to put advantix and advantage ii simultaneously on a larger dog? advantix for l and advantage ii for sm.  that amount needed for bigger dog.**
A: Each box will have a different expiration date on it. We had a box for at least a year, it still worked on the dog.

**Q: What are ingredients?**
A: Strange that they leave this part out of the description as it is rather important. I have used this product on several dogs for years and purchased here and the online pet pharmacy out of Canada (wife ordered and I forget the name) but never had a problem but just like humans, some dogs have different reactions than others to certain products/chemicals, so do be careful to follow directions and monitor a bit to make sure your pet is taking it as expected and not having any reactions.  Since they don't list it, I would email them seller directly, and/or look on the manufacturer website for more info.

**Q: what is the difference between Advantage 11 and Advantage?**
A: Advantage II Is a better flea control and does not wash off as does Advantage.  Advantage II is what you want!

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by J***R on 5 December 2025*

Works for all 3 of my dogs, no fleas, no ticks! I buy this product every summer!

### ⭐⭐⭐⭐⭐ Review
*by R***H on 16 December 2025*

I have never had a problem getting rid of fleas with Advantage

### ⭐⭐⭐⭐⭐ Review
*by T***S on 9 January 2016*

I know there are A-LOT of bad reviews for these but my belief is that people are using the product wrong, possibly issuing wrong doses or ordering the wrong product size. Bayer is a local, well known, trusted company in my area and I can tell you that they do not manufacture products that would kill your animals or harm them. This is a local, USA company. I have had family members that have worked for them their entire lives. Now on to the product. It works very well. We were using Frontline but it did not work. AT ALL. Our dog was getting ticks, our cats and dog had fleas. We used Frontline religiously and it just didn't perform. We ended up with a really bad flea infestation in our home and we needed to take action as multiple flea baths and house treatment were not helping. We finally switched to advantage II. Weary about the reviews we applied it to our animals in the proper dosage, size, and areas. Read, read and re-read the instructions. There are specific ways to apply this for specific animals. There are also specific sizes that you purchase depending on the type and weight of your animal. YOU NEED TO READ! Within two weeks after we treated our house with products known as permethrin and I.G. regulators as well as using Bayer Advantage II we completely got rid of our flea problem. Its now been months since we have had the problem and we haven't found a single flea on our animals. This stuff just hands down works. I would recommend to anybody and I'm going to keep purchasing it because I never want to have fleas in my home again. Its well worth the price. UPDATE: Its now been 5 years since my original review and we still use this. We have not had a single flea issue since my original review. Our animals are safe and healthy. Be aware that there are counterfeits on Amazon. There are articles on the internet of what to check for. If you are concerned, purchase it from your vet or Chewy.

## Frequently Bought Together

- Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply
- Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply
- Advantage II Medium Dog Vet-Recommended Flea Treatment & Prevention | Dogs 11-20 lbs. | 4-Month Supply

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---

*Product available on Desertcart Senegal*
*Store origin: SN*
*Last updated: 2026-02-02*