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🐾 Stay ahead of pests with the #1 vet-trusted flea & tick shield!
FRONTLINE Plus for Medium Dogs (23-44 lbs) delivers fast, long-lasting flea and tick protection with a single monthly topical dose. Waterproof after 24 hours, it kills adult fleas, eggs, larvae, ticks, chewing lice, and mites by targeting the entire flea life cycle. Trusted by pet owners for over 20 years, this easy-to-apply treatment spreads through the skin’s sebaceous glands to protect your dog’s whole body, ensuring continuous defense even after swimming or rain.


















| ASIN | B0002J1FNK |
| Active Ingredients | fipronil and (S)-methoprene |
| Age Range Description | All Life Stages |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #314 in Pet Supplies ( See Top 100 in Pet Supplies ) #5 in Dog Flea Drops |
| Brand | Frontline |
| Brand Name | Frontline |
| Customer Reviews | 4.4 out of 5 stars 23,941 Reviews |
| Dog Breed Size | Medium |
| Included Components | Package includes 6 applicators |
| Item Form | Liquid |
| Item Type Name | Flea and Tick Treatment for Dogs Medium Dogs |
| Item Volume | 24 Milliliters |
| Item Weight | 1.6 ounces |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer Part Number | P004FLTSP6-23-44 |
| Model Number | P004FLTSP6-23-44 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Medium Dog, 23-44 Pounds |
| UPC | 350604288107 |
| Unit Count | 1 Count |
| Volume | 24 Milliliters |
| Warranty Description | If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842 |
C**R
worked very quick
I don’t have a pic for my review but I put this on my dog after seeing some fleas. It only took two days to get in the mail. I put it on my dog and didn’t notice any fleas after a day. It blended in very quick. He probably was only oily in that spot for a day or two. It didn’t have a strong scent.
B**A
Excellent product, BUT...
This is an excleent product, but it is not a miracle worker. In other words, you need to use the stuff properly. (1) this product is water resistant...not soap resistant. So if you use this stuff then go and use some of that heavily perfumes soapy shampoo that msot people use..then you are washign it right off. (2) if you chose to bathe your dog..bathe him/her first then wait 2-3 days THEN apply the product so that it will be distrubited properly. (3) Remember that if you have a heavy flea problem that you need to treat the pet and the environment. You can't jsut put it on the dog and not get rid of the fleas in your house, car, yard, etc.. Yeah it will kill the fleas on him/her, but they will get reinfested with fleas everytime they go back into the flea filled environment. This is the only product that I use for my dog. Of you purchase ANYTHING over the counter (biospot, hartz ::shudders::, etc) then you are wasting your money. Flea dips work, but they only kill the fleas that are on the dog when you bathe him/her. Frontline PLUS is great becasue it keeps killing for up to a month. Also, Frontline Plus has a better range of killing fleas than plain ole' Frontline. The "PLUS" means that it kills larvae and eggs and so much more than adult fleas. IF USED CORRECTLY and ROUTINELY this is an EXCELLENT product!!! I highly recommend it. This product also kills ticks.
M**N
Dog Flea and tick - good quality
So far so good.
A**.
Trusted protection, but effectiveness can vary by region
This is a well-known and trusted flea & tick treatment that’s easy to use and works as part of a monthly routine. Each application provides about 30 days of protection, and the formula is designed to kill adult fleas, eggs, larvae, ticks, and even chewing lice. Application is simple—just apply it to the back of your dog’s neck, and it spreads through the oils in the skin for full-body protection. It’s also waterproof after drying, which is helpful for active dogs. In terms of performance, it works well for many dogs and can kill adult fleas within about 12 hours and ticks within 48 hours, helping break the flea life cycle. On the downside, effectiveness can vary depending on your area—some users report it’s not as strong as it used to be, especially in high-flea regions. It can also take a full day or so to start working, and you’ll need to stay consistent with monthly use.
B**T
Gets rid of pests
FRONTLINE Plus has been very effective at keeping fleas and ticks under control. It’s easy to apply, doesn’t have a strong odor, and hasn’t caused any irritation. I like that it provides long lasting protection with just one monthly dose. This has been a reliable product for us and definitely worth the purchase. Your pets will be happy you bought it.
D**Z
Frontline is perfect for monthly maintenance!
Use this once a month for my dog. It does exactly what it's supposed to. Just make sure you read the directions to make sure you're getting the right size for your pet. Super easy to open. My papa has had no skin irritation, or discomfort after I apply it. Definitely a must to avoid any type of flea or tick infestation
T**Z
Doesn’t work in March in San Antonio TX at all!!
Not working so well. Have been using on the absolute reg and dog still getting ticks. They don’t die either!! She also gets the oral stuff regularly and I spray the yard! What the heck!! I also spray her bedding etc w the natural stuff and her as well. Really the natural spray is the only decent stuff but can’t spray her constantly. Do spray bedding twice a day. Any suggestions will be appreciated. No one wants to see a pic of ticks. 😬😵💫
J**Y
Good
Did what supposed to do
D**L
Wrning it is NOT the 6-dose pack so very overpriced when you only get three
It says 6-doses but what arrived was only the 3-dose pack.
Trustpilot
2 months ago
1 month ago