Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding

This book belongs in every protein biochemists collection. It is a clear, up-to-date review of protein structure and function, with a concentration on enzymes. It covers a host of vital topics, including: the theories of chemical catalysis, enzyme kinetics (buy Segal for an in-depth study of this topic), the methods for determining rate constants, the stereochemistry of enzyme reactions, various regulation mechanisms, binding energies and the forces between molecules, and an overview of protein engineering techniques. If all this were not enough, Fersht concludes with a wonderful chapter covering case studies of enzyme structure and mechanism, and another couple on the kinetics and mechanisms of protein folding. Extensive references are given to the current literature for further study. Putting all these topics into one book is an accomplishment that few authors could pull off - but Fersht does it extremely well! Oh - the other nine ? Cornish-Bowden, "Principles of Enzyme Kinetics"; Segal, "Enzyme Kinetics"; Voet & Voet, "Biochemistry"; Branden & Tooze, "Introduction to Protein Science"; Dixon & Web, "Enzymes"; Pauling, "The Nature of the Chemical Bond"; Scopes, "Protein Purification"; Freifelder, "Physical Biochemistry"; Walsh, "Enzymatic Reaction Mechanisms"

A valuable reference, rich in graphs, tables, and citations. Chapters include topics covering the following: - catalysis - enzyme kinetics - measuring rate constants - pH dependence - equilibria - intermediates - stereochemistry - inhibition, regulation - binding energies - specificity and affinity - recombinant DNA technology - protein engineering - case studies in structure & function - stability and folding kinetics - folding and energy landscapes Knowing what it covers, I'd recommend this book only to serious undergraduates (with at least 1 year of physical chemistry and biochemistry each) or to graduate students...or diehard science literate people. Each chapter is thoroughly cited for further reading pleasure.

Delivery: Said that it would be delivered in 4 to 6 weeks but came within two weeks. Textbook quality: the textbook was not used. Except for some wear on the cover, the pages were crisp and didn't contain writing or highlighting.

The book arrived fast and in a good quality. The cover and the pages are clean and without any scrawl. I am really enjoying my new book.

The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text. Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding. Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

Great book for those studying enzymes. Contains lots of info and is a great source for papers. I would highly recommend this book.

It is a good book!

Man, this book rocked! I took one look at the ribbon structure of ATPase on the cover and said to myself, "Whoa dude! This is, like, phat!" Then I turned the pages and BAM! I was knee deep in protein structure! Like, any first-year biochemist knows its all about the acids, as in amino, and Fersht, he knows his peptides! Oh man, I was on cloud nine! And I've been off my meds for two months now! But you wanna know the real dope? You can't say diddly about function unless you know structure, and that Alan, as in Fersht, dude! Like, he starts you off simple, like, you know, with the "building blocks," like we're a bunch of two-year-olds, and you string 'em together and get all that higher-order structure and stuff, and slowly, ever so slowly, like a mental itch that invades your consciousness and becomes screaming voices telling you to AHHHHHHHHH! So many domains! Too many functional units! No, no, nooooooo! Schiff base? Shift Bass! Ah HA HA HA HA! What do all those K's mean!?! Take me home! Please...

One of the powerful books about proteins and enzyme catalysis

Good book ! Really useful and clear !

Están vendiendo basura y por 200.00 pesos. El excelente libro de Fersht: Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding, que se compra para Kindle, consiste solamente de dos páginas, la portada y una página interior y seguro que el formato es pdf. Si van a poner el libro en el formato para Kindle, que sea el libro completo. Deberían de quitar esta opción fantasma de su página.

Very important for Biochemists